This session examines the impact of putting research into the hands of those who are not normally seen as the primary drivers of health systems change. Using integrated findings from two multi-methods programs of research, we focus on four elements of the WHO framework for health systems strengthening: governance, health human resources, financing and information systems.. The first program aimed to build capacity for health systems linkages between community-based structures and district health services. It was undertaken in an urban slum, a rural district and a nomadic area of Kenya from 2009-12. The second research program, undertaken between 2007 and 2012, aimed to engage front line nurses in the policy process related to HV/AIDS. Three intervention districts were selected in each participating country: Kenya, Uganda, South Africa and Jamaica. Presentations will highlight qualitative findings from interviews with key stakeholders, community representatives and health workers; and quantitative findings from questionnaires administered to health workers and households. Dr. Kaseje will highlight innovative features of the research programs. This will be followed by four oral presentations and audience discussion. Dr. Edwards will conclude by describing critical processes, outcomes and challenges.