Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe haemophilia in Iran

Cost-effectiveness of prophylaxis against on-demand treatment in boys with severe haemophilia in[1]

A.K.Daliri A[2], Mamikhani J.[3]

Objective: The aim of this study was to assess the incremental cost-effectiveness of on-demand versus prophylactic haemophilia therapy in from the third-party payers’ perspective.

Setting: Three hemophilia treatment centers in.

Methods: A retrospective chart review of 25 types A haemophiliacs that treated in 3 hemophilia treatment center was conducted for patients aged 0- 9 years receiving one of two treatments: (i) prophylaxis with concentrate at clinic;(ii) concentrate at clinic as on-demand. 14 boys receiving on-demand infusions for bleeding events and 11 boys receiving infusions prophylaxis. Data were collected from documents obtained from the hemophilia treatment centers during a period of approximately 6 months.

Results: The patients receiving prophylactic treatment had fewer bleeding events each month (mean, 0.26 vs. 2.74) but used more concentrate (225.31 vs. 92.67 units / kg per month). Average cost per patient each month at prophylaxis group was about 1.9 times higher than on-demand group. Compared with on-demand infusion, prophylaxis costs 3200985 Rials per bleeding event prevented.

Conclusion: Prophylactic care markedly reduces the number of bleeding events, but at substantial cost.

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[1]. This article is base on a project which was financed by Health Ministry of Iran and was conducted in cooperation with Behinpuyan Research Institute. 

[2].Correspondence: M.S in Health Economics, University Lecturer in Shiraz University of Medical Sciences. Alik2003@gmail.com