Professional migration from developing countries is a loss of the most qualified human capital to the developed world that offer stability, professional growth and better socioeconomic and living standards. On the other hand it is an undeniable right of individual freedom to choose where to live and to work. However, the investment of the sending countries into education should be compensated; different approaches for that will be discussed including the positions of WFPHA and WHO. Over the last few decades, due to the complex interplay of pull and push factors, the outflow of human capital in large numbers from developing to rich and developed countries has remained a major development challenge. Paucity of information on migration of professionals including health professionals is a serious setback to exactly quantify the enormity of the problem. However despite continued effort in training, shortage of skilled human resources is emerging as one of the crucial factors that hinder the development of knowledge-based societies. Hence avoiding further depletion of Human Capital would ensure national competitiveness in production, distribution and utilization of goods and services in the global market. It could also lead to improvement in the overall socio economic and technological development of these countries. On the other hand, the gaining rich countries have continued to strategically open their doors to attract scarce skills to meet their institutional aspirations and societal needs. In recent years, a number of developed countries have introduced policies and strategies that would help the in-flow of qualified immigrants to these countries. To address these challenges and to ensure fulfillment of their quest for rapid growth and sustainable development, engaging the brain power of professionals including those in the diaspora is imperative for developing countries. Professionals including health professionals in the diaspora along with their second and third generation are among the critical resource whose maximum mobilization and engagement is indispensible. But the extent to which migrant professionals can contribute to the development of their country of origin is dependent largely on policies, institutional frameworks and socio-economic environments in home and host countries. Ensuring national, regional and international coherence on migration and development policies, including accountability and global social responsibilities, will assist decision makers to manage migration more effectively and harness the benefits as a tool in development strategies. Policy coherence must therefore be approached at different levels and involve different stakeholders to avoid the direct and indirect negative effects of competing policy agendas. The discussion will examine the enormity of and worsening trend of the problem and major actions taken so far; highlight the role of the various stakeholders to mitigate the problem and; make some novel recommendations that call upon the joint action of national, regional and global players for a new era of constructive engagement.