Treatment Outcome of Tuberculosis Patients Under Directly Observed Treatment in Addis Ababa, Ethiopia: A Retrospective Cohort Study

Tuesday, April 24, 2012
A: Halfdan T. Mahler Hall (Millennium Hall)
Belete Getahun Armauer Hansen Research Institute, Ethiopia
Dr.Gobena Ameni Aklilu Lemma Institute of Pathobiology, College of Health Sciences, Ethiopia
Girmay Medhin Aklilu Lemma Institute of Pathobiology, College of Health Sciences, Ethiopia
Sibhatu Biadgilign University of Maryland School of Medicine-Institute of Human Virology, AIDSRelief Program, Ethiopia
Background: Tuberculosis (TB) is the leading cause of mortality among infectious diseases worldwide. For effective TB control it is a pre-requisite to detect the cases as early as possible, and to ensure that the cases complete their treatment and get cured. In many resource-constrained settings treatment outcomes for TB have not been satisfactory.

Objective: To assess the treatment outcome and factors associated with treatment success among TB patients under DOTS program in government owned health institutions in Addis Ababa, Ethiopia.

Methods: A register based retrospective cohort study covering the period of July 2004 to June 2009 was conducted to determine the outcome of DOTS in government owned health institutions in Addis Ababa. For each of the recorded patient we extracted information on demographic characteristics, treatment centre, year of treatment, type of TB, treatment given to the patient, and follow-up and treatment outcomes.

Result: A total of 6,450 registered TB patients were included in this study and 46.8 % of them were male. Of these patients 1167(18.1%) were cured, 4164(64.6%) were documented as treatment completed, 236(3.7%) were died, 328(5.1%) were reported as defaulted, 26(0.4%) were cases of treatment failure, 351(5.4%) were transferred out and 178(2.8%) had unknown treatment outcomes. Having negative baseline smear result, being a male patients, not being in the age group of 35-64 years, and year of treatment being outside 2005- 2007 were significantly associated with increased likelihood of treatment successes. Treatment center is also significantly associated with the probability of treatment success  

Conclusion: The overall treatment success rate obtained in this study is in line with WHO target of 85% for the year 2005. Male patients and treatment center were significant determinants of treatment success. Continuous follow up of patients during treatment course, strengthen the recording system, focusing on female gender is recommended. Treatment Outcome, TB, DOT, Cohort, Ethiopia


Learning Objectives: Treatment Outcome in a cohort of Tuberculosis Patients
See more of: Millennium Development Goals (MDGs)
See more of: Achieving Millennium Development Goals: Vital for Global Health Equity
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